4ARK
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 | polymer | 341 | 37930.6 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | MAP KINASE KINASE 1, MAPKK 1, MKK1, ERK ACTIVATOR KINASE 1, MAPK/ERK KINASE 1, MEK 1 |
2 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | 2-([3R-3,4-dihydroxybutyl]oxy)-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]benzamide | non-polymer | 478.2 | 1 | Chemie (M3K) | |||
5 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 62 - 393 (UniProt: Q02750)
PDB | External Database | Details |
---|---|---|
Met 61 | - | expression tag |
Leu 394 | - | expression tag |
Glu 395 | - | expression tag |
His 396 | - | expression tag |
His 397 | - | expression tag |
His 398 | - | expression tag |
His 399 | - | expression tag |
His 400 | - | expression tag |
His 401 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37930.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 929.7 | |
All* | Total formula weight | 38860.3 |