4APN

Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor

4APN の概要

• エントリーDOI: 10.2210/pdb4apn/pdb
• 関連するPDBエントリー: 2JK6 2W0H 2X50 2YAU 4ADW
• 分子名称: TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, trypanosomatids
• 由来する生物種: LEISHMANIA INFANTUM
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115267.63

構造登録者

Baiocco, P.,Ilari, A.,Colotti, G.,Biava, M. (登録日: 2012-04-04, 公開日: 2013-04-17, 最終更新日: 2023-12-20)

• 主引用文献: Baiocco, P.,Poce, G.,Alfonso, S.,Cocozza, M.,Porretta, G.C.,Colotti, G.,Biava, M.,Moraca, F.,Botta, M.,Yardley, V.,Fiorillo, A.,Lantella, A.,Malatesta, F.,Ilari, A.; Inhibition of Leishmania Infantum Trypanothione Reductase by Azole-Based Compounds: A Comparative Analysis with its Physiological Substrate by X-Ray Crystallography.; Chemmedchem, 8:1175-, 2013; PubMed: 23733388; DOI: 10.1002/CMDC.201300176

実験手法

X-RAY DIFFRACTION (3.2 Å)