4AOV

DpIDH-NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism

Summary for 4AOV

Entry DOI	10.2210/pdb4aov/pdb
Related	2UXQ 2UXR 4AOU
Descriptor	ISOCITRATE DEHYDROGENASE [NADP], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, temperature adaptation, thermophilic, psychrophilic, nadp+ selectivity, domain movements
Biological source	DESULFOTALEA PSYCHROPHILA
Total number of polymer chains	1
Total formula weight	46608.96
Authors	Leiros, H.-K.S.,Fedoy, A.-E.,Leiros, I.,Steen, I.H. (deposition date: 2012-03-30, release date: 2012-07-11, Last modification date: 2024-05-08)
Primary citation	Leiros, H.-K.S.,Fedoy, A.-E.,Leiros, I.,Steen, I.H. The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila Suggest a New Active Site Locking Mechanism FEBS Open Bio., 2:159-, 2012 Cited by PubMed: 23650595 DOI: 10.1016/J.FOB.2012.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation