4AOU

CtIDH bound to NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism

Summary for 4AOU

• Entry DOI: 10.2210/pdb4aou/pdb
• Related: 4AOV
• Descriptor: ISOCITRATE DEHYDROGENASE [NADP], ISOCITRIC ACID, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: oxidoreductase, temperature adaptation, thermophilic, psychrophilic, nadp+ selectivity, domain movements
• Biological source: CLOSTRIDIUM THERMOCELLUM
• Total number of polymer chains: 1
• Total formula weight: 46802.03

Authors

Leiros, H.-K.S.,Fedoy, A.-E.,Leiros, I.,Steen, I.H. (deposition date: 2012-03-30, release date: 2012-07-11, Last modification date: 2024-05-08)

• Primary citation: Leiros, H.K.,Fedoy, A.E.,Leiros, I.,Steen, I.H.; The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism.; Febs Open Bio, 2:159-172, 2012; PubMed: 23650595; DOI: 10.1016/j.fob.2012.06.003

Experimental method

X-RAY DIFFRACTION (2.5 Å)