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4AOV

DpIDH-NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0006099biological_processtricarboxylic acid cycle
A0006102biological_processisocitrate metabolic process
A0006739biological_processNADP metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues34
DetailsBINDING SITE FOR RESIDUE NAP A 1403
ChainResidue
AALA73
AHIS305
AGLY306
ATHR307
AVAL308
AARG310
AHIS311
ATHR323
AASN324
AICT1404
AHOH2042
ATHR74
AHOH2045
AHOH2115
AHOH2141
AHOH2143
AHOH2163
AHOH2164
AHOH2165
AHOH2166
AHOH2178
AHOH2190
ATHR76
AHOH2192
AHOH2199
AHOH2225
AHOH2226
AHOH2227
AARG81
AASN95
AASP250
AARG254
ALEU285
AALA286

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ICT A 1404
ChainResidue
ATHR76
ASER93
AASN95
AARG99
AARG108
AARG131
ATYR138
ALYS209
AILE212
AASP249
AASP272
AALA304
ANAP1403
AMG1405
AHOH2067
AHOH2141
AHOH2143
AHOH2177

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1405
ChainResidue
AASP249
AASP272
AICT1404
AHOH2067
AHOH2177

Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVmSDmvAsaf.GSLAM
ChainResidueDetails
AASN268-MET287

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PDB entries from 2024-06-12

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