4ALX

Crystal Structure of Ls-AChBP complexed with the potent nAChR antagonist DHbE

Summary for 4ALX

• Entry DOI: 10.2210/pdb4alx/pdb
• Related: 1I9B 1UV6 1UW6 1UX2
• Descriptor: ACETYLCHOLINE BINDING PROTEIN, (4bS,6S)-6-methoxy-1,4,6,7,9,10,12,13-octahydro-3H,5H-pyrano[4',3':3,4]pyrido[2,1-i]indol-3-one, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: acetylcholine-binding protein, lymnaea stagnalis, dihydro-b-erythroidine, antagonist, c-loop
• Biological source: LYMNAEA STAGNALIS (GREAT POND SNAIL)
• Cellular location: Secreted: P58154
• Total number of polymer chains: 10
• Total formula weight: 265202.04

Authors

Shahsavar, A.,Kastrup, J.S.,Nielsen, E.O.,Kristensen, J.L.,Gajhede, M.,Balle, T. (deposition date: 2012-03-06, release date: 2012-08-29, Last modification date: 2018-01-17)

• Primary citation: Shahsavar, A.,Kastrup, J.S.,Nielsen, E.O.,Kristensen, J.L.,Gajhede, M.,Balle, T.; Crystal Structure of Lymnaea Stagnalis Achbp Complexed with the Potent Nachr Antagonist Dh-Betab-E Suggests a Unique Mode of Antagonism; Plos One, 7:40757-, 2012; PubMed: 22927902; DOI: 10.1371/JOURNAL.PONE.0040757

Experimental method

X-RAY DIFFRACTION (2.3 Å)