Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ALX

Crystal Structure of Ls-AChBP complexed with the potent nAChR antagonist DHbE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IZN A 400

Chain	Residue
A	TYR89
A	TRP143
A	CYS187
A	TYR192
B	GLN55
B	LEU112
B	MET114

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 1211

Chain	Residue
A	LEU63
A	ALA64
A	TRP65
I	ASN9
I	LEU63
A	ASN9
A	THR13

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN B 400

Chain	Residue
B	TYR89
B	TRP143
B	TYR185
B	CYS187
B	TYR192
B	HOH2040
C	TRP53
C	LEU112
C	MET114

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 1PE B 1206

Chain	Residue
B	GLN54
B	LEU86
B	ALA87
B	ALA88
B	LYS94
B	PRO95
B	ILE117
B	GLN119
B	HOH2035
B	HOH2056
B	HOH2057
C	LEU98
C	PRO100

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1207

Chain	Residue
B	ASP2
B	HOH2058
I	ASP2

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN C 400

Chain	Residue
C	TYR89
C	TRP143
C	THR144
C	TYR185
C	CYS187
C	TYR192
D	GLN55
D	LEU112
D	MET114

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN D 400

Chain	Residue
D	TYR89
D	TRP143
D	TYR185
D	CYS187
D	TYR192
E	TRP53
E	GLN55
E	LEU112
E	MET114

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 1205

Chain	Residue
D	TYR164
D	HOH2086

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 1206

Chain	Residue
D	HOH2088

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN E 400

Chain	Residue
A	GLN55
A	LEU112
A	TYR113
A	MET114
E	TYR89
E	TRP143
E	THR144
E	CYS187
E	TYR192

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN F 400

Chain	Residue
F	TYR89
F	TRP143
F	TYR185
F	CYS187
F	TYR192
G	TRP53
G	ARG104
G	LEU112
G	MET114

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE F 1206

Chain	Residue
D	ASN9
F	ASN9
F	ILE10
F	THR13
F	THR62
F	LEU63
F	ALA64
F	TRP65

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 1207

Chain	Residue
F	ASP108
F	HOH2053
I	SER151

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 1208

Chain	Residue
E	ASP2
E	HOH2001
F	ASP2
F	ASP5

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN G 400

Chain	Residue
H	GLN55
H	LEU112
H	MET114
G	TYR89
G	TRP143
G	CYS187
G	TYR192
G	HOH2066
H	TRP53

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PE G 1206

Chain	Residue
C	THR13
C	THR62
C	LEU63
C	ALA64
C	TRP65
G	ASN9
G	ILE10
G	THR62
G	LEU63
G	ALA64
G	TRP65

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IZN H 400

Chain	Residue
H	TYR89
H	TRP143
H	THR144
H	TYR185
H	CYS187
H	TYR192
I	TRP53
I	GLN55
I	LEU112
I	MET114

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1PE H 1206

Chain	Residue
B	ASN9
B	THR13
B	THR62
B	LEU63
B	TRP65
H	ASN9
H	ILE10
H	THR13
H	THR62
H	ALA64
H	TRP65
H	HOH2065

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN I 400

Chain	Residue
I	TYR89
I	TRP143
I	TYR185
I	CYS187
I	TYR192
J	TRP53
J	GLN55
J	LEU112
J	MET114

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZN J 400

Chain	Residue
F	GLN55
F	LEU112
F	MET114
F	HOH2052
J	TYR89
J	TRP143
J	THR144
J	CYS187
J	TYR192

site_id	CC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PE J 1206

Chain	Residue
E	ASN9
E	THR62
E	ALA64
J	LEU1
J	ASN9
J	ILE10
J	THR13
J	THR62
J	LEU63
J	ALA64
J	TRP65

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 1207

Chain	Residue
A	ASP2
F	GLU157
J	ASP2
J	ASP5
J	HOH2001

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN66
J	ASN66
B	ASN66
C	ASN66
D	ASN66
E	ASN66
F	ASN66
G	ASN66
H	ASN66
I	ASN66

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)