4AKC

Structure of Galactose Binding lectin from Champedak (CGB) with Gal(beta)1,3-GalNac

Summary for 4AKC

• Entry DOI: 10.2210/pdb4akc/pdb
• Related: 4AK4 4AKB 4AKD
• Related PRD ID: PRD_900084
• Descriptor: AGGLUTININ ALPHA CHAIN, AGGLUTININ BETA-4 CHAIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (4 entities in total)
• Functional Keywords: sugar binding protein, mannose
• Biological source: ARTOCARPUS INTEGER; More
• Total number of polymer chains: 8
• Total formula weight: 68816.76

Authors

Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. (deposition date: 2012-02-22, release date: 2013-02-27, Last modification date: 2023-12-20)

Primary citation

Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J.
Structures and Binding Specificity of Galactose- and Mannose-Binding Lectins from Champedak: Differences from Jackfruit Lectins
Acta Crystallogr.,Sect.F, 70:709-, 2014

PubMed Abstract: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.

PubMed: 24915077
DOI: 10.1107/S2053230X14008966

Experimental method

X-RAY DIFFRACTION (2.3 Å)