4AKC

Structure of Galactose Binding lectin from Champedak (CGB) with Gal(beta)1,3-GalNac

4AKC の概要

• エントリーDOI: 10.2210/pdb4akc/pdb
• 関連するPDBエントリー: 4AK4 4AKB 4AKD
• 関連するBIRD辞書のPRD_ID: PRD_900084
• 分子名称: AGGLUTININ ALPHA CHAIN, AGGLUTININ BETA-4 CHAIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (4 entities in total)
• 機能のキーワード: sugar binding protein, mannose
• 由来する生物種: ARTOCARPUS INTEGER; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 68816.76

構造登録者

Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. (登録日: 2012-02-22, 公開日: 2013-02-27, 最終更新日: 2023-12-20)

主引用文献

Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J.
Structures and Binding Specificity of Galactose- and Mannose-Binding Lectins from Champedak: Differences from Jackfruit Lectins
Acta Crystallogr.,Sect.F, 70:709-, 2014

PubMed Abstract: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.

PubMed: 24915077
DOI: 10.1107/S2053230X14008966

実験手法

X-RAY DIFFRACTION (2.3 Å)