4AJW
Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
4AJW の概要
エントリーDOI | 10.2210/pdb4ajw/pdb |
関連するPDBエントリー | 2WXE 2WXF 2WXG 2WXH 2WXI 2WXJ 2WXK 2WXL 2WXM 2WXN 2WXO 2WXP 2WXQ 2WXR 2X38 |
分子名称 | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(1-methyl-1H-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3H)-one (3 entities in total) |
機能のキーワード | transferase, p110d |
由来する生物種 | MUS MUSCULUS (HOUSE MOUSE) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 215070.78 |
構造登録者 | Certal, V.,Halley, F.,Virone-Oddos, A.,Delorme, C.,Karlsson, A.,Rak, A.,Thompson, F.,Filoche-Romme, B.,El-Ahmad, Y.,Carry, J.C.,Abecassis, P.Y.,Lejeune, P.,Bonnevaux, H.,Nicolas, J.P.,Bertrand, T.,Marquette, J.P.,Michot, N.,Benard, T.,Below, P.,Vade, I.,Chatreaux, F.,Lebourg, G.,Pilorge, F.,Angouillant-Boniface, O.,Louboutin, A.,Lengauer, C.,Schio, L. (登録日: 2012-02-20, 公開日: 2012-05-16, 最終更新日: 2023-12-20) |
主引用文献 | Certal, V.,Halley, F.,Virone-Oddos, A.,Delorme, C.,Karlsson, A.,Rak, A.,Thompson, F.,Filoche-Romm, B.,El-Ahmad, Y.,Carry, J.C.,Abecassis, P.Y.,Lejeune, P.,Vincent, L.,Bonnevaux, H.,Nicolas, J.P.,Bertrand, T.,Marquette, J.P.,Michot, N.,Benard, T.,Below, P.,Vade, I.,Chatreaux, F.,Lebourg, G.,Pilorge, F.,Angouillant-Boniface, O.,Louboutin, A.,Lengauer, C.,Schio, L. Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. J.Med.Chem., 55:4788-, 2012 Cited by PubMed: 22524426DOI: 10.1021/JM300241B 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
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