4AJW
Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM | polymer | 934 | 107210.0 | 2 | UniProt (O35904) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | MUS MUSCULUS (HOUSE MOUSE) | PI3-KINASE SUBUNIT DELTA, PI3K-DELTA, PI3KDELTA, PTDINS-3-KINASE SUBUNIT DELTA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT DELTA, PTDINS-3-KINASE SUBUNIT P110-DELTA, P110DELTA |
| 2 | C, D (A, B) | 2-[(1-methyl-1H-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3H)-one | non-polymer | 325.4 | 2 | Chemie (VWN) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 214420.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 650.7 | |
| All* | Total formula weight | 215070.8 |
