2WXJ

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654.

Summary for 2WXJ

Entry DOI	10.2210/pdb2wxj/pdb
Related	2WXE 2WXF 2WXG 2WXH 2WXI 2WXK 2WXL 2WXM 2WXN 2WXO 2WXP 2WXQ 2WXR
Descriptor	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, N-[6-(4-amino-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzothiazol-2-yl]acetamide (3 entities in total)
Functional Keywords	transferase, phosphoprotein, isoform-specific inhibitors, cancer, nucleotide-binding
Biological source	MUS MUSCULUS (MOUSE)
Total number of polymer chains	1
Total formula weight	108388.33
Authors	Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. (deposition date: 2009-11-09, release date: 2010-01-12, Last modification date: 2023-12-20)
Primary citation	Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol., 6:117-, 2010 Cited by PubMed: 20081827 DOI: 10.1038/NCHEMBIO.293 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation