4AGU

CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN

Summary for 4AGU

Entry DOI	10.2210/pdb4agu/pdb
Descriptor	CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide (3 entities in total)
Functional Keywords	transferase, phospho-mimetic, kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q00532
Total number of polymer chains	3
Total formula weight	110264.42
Authors	Canning, P.,Sharpe, T.D.,Allerston, C.,Savitsky, P.,Pike, A.C.W.,Muniz, J.R.C.,Chaikuad, A.,Kuo, K.,Burgess-Brown, N.,Ayinampudi, V.,Zhang, Y.,Thangaratnarajah, C.,Ugochukwu, E.,Vollmar, M.,Krojer, T.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Knapp, S.,Bullock, A. (deposition date: 2012-01-31, release date: 2012-02-08, Last modification date: 2023-12-20)
Primary citation	Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175 DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation