4AGU
CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | CYCLIN-DEPENDENT KINASE-LIKE 1 | polymer | 311 | 36306.9 | 3 | UniProt (Q00532) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | |
| 2 | D, E, F (A, B, C) | N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide | non-polymer | 447.9 | 3 | Chemie (D15) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 300 (UniProt: Q00532)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | cloning artifact |
| Asp 301 | - | expression tag |
| Lys 302 | - | expression tag |
| Pro 303 | - | expression tag |
| Ala 304 | - | expression tag |
| Glu 305 | - | expression tag |
| Asn 306 | - | expression tag |
| Leu 307 | - | expression tag |
| Tyr 308 | - | expression tag |
| Phe 309 | - | expression tag |
| Gln 310 | - | expression tag |
| Thr 152 | Ala 152 | variant |
| Asp 159 | Thr 159 | engineered mutation |
| Glu 161 | Tyr 161 | engineered mutation |
| Glu 274 | Gln 274 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 108920.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1343.8 | |
| All* | Total formula weight | 110264.4 |
