4AGD

CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-diethylaminoethyl)-5-((Z)-(5- fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide)

Summary for 4AGD

Entry DOI	10.2210/pdb4agd/pdb
Related	1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AG8 4AGC 4ASD 4ASE
Descriptor	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total)
Functional Keywords	transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	40656.87
Authors	McTigue, M.,Deng, Y.,Ryan, K.,Brooun, A.,Diehl, W.,Stewart, A. (deposition date: 2012-01-26, release date: 2012-09-26, Last modification date: 2023-12-20)
Primary citation	Mctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S. Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109:18281-, 2012 Cited by PubMed: 22988103 DOI: 10.1073/PNAS.1207759109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation