4AG8

CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)

Summary for 4AG8

Entry DOI	10.2210/pdb4ag8/pdb
Related	1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AGC 4AGD 4ASD 4ASE
Descriptor	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, AXITINIB (3 entities in total)
Functional Keywords	transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36581.23
Authors	McTigue, M.,Wickersham, J.,Pinko, C.,Kania, R.S.,Bender, S. (deposition date: 2012-01-24, release date: 2012-09-26, Last modification date: 2023-12-20)
Primary citation	Mctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S. Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109:18281-, 2012 Cited by PubMed: 22988103 DOI: 10.1073/PNAS.1207759109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation