4AG8
CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | polymer | 316 | 36194.8 | 1 | UniProt (P35968) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | VEGFR-2, FETAL LIVER KINASE 1, FLK-1, KINASE INSERT DOMAIN RECEPTOR, KDR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, CD309 |
| 2 | B (A) | AXITINIB | non-polymer | 386.5 | 1 | Chemie (AXI) | |||
| 3 | C (A) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
A: 990 - 1171 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Val 990 | Glu 990 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36194.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.5 | |
| All* | Total formula weight | 36581.2 |
