4AG3

Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with NADPH at 1.8A resolution

Summary for 4AG3

• Entry DOI: 10.2210/pdb4ag3/pdb
• Related: 4AFN
• Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PENTAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: fatty acid biosynthesis, oxidoreductase, rossmann fold
• Biological source: PSEUDOMONAS AERUGINOSA
• Total number of polymer chains: 4
• Total formula weight: 116814.33

Authors

Cukier, C.D.,Schnell, R.,Schneider, G.,Lindqvist, Y. (deposition date: 2012-01-24, release date: 2013-02-06, Last modification date: 2023-12-20)

• Primary citation: Cukier, C.D.,Hope, A.,Elamin, A.,Moynie, L.,Schnell, R.,Schach, S.,Kneuper, H.,Singh, M.,Naismith, J.,Lindqvist, Y.,Gray, D.,Schneider, G.; Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa; Acs Chem.Biol., 8:2518-, 2013; PubMed: 24015914; DOI: 10.1021/CB4005063

Experimental method

X-RAY DIFFRACTION (1.8 Å)