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4AF3

Human Aurora B Kinase in complex with INCENP and VX-680

Summary for 4AF3
Entry DOI10.2210/pdb4af3/pdb
DescriptorAURORA KINASE B, INNER CENTROMERE PROTEIN, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total)
Functional Keywordstransferase-inhibitor complex, aurkb, transferase/inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationNucleus: Q96GD4 Q9NQS7
Total number of polymer chains2
Total formula weight42400.17
Authors
Elkins, J.M.,Vollmar, M.,Wang, J.,Picaud, S.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,von Delft, F.,Knapp, S. (deposition date: 2012-01-16, release date: 2012-04-11, Last modification date: 2023-12-20)
Primary citationElkins, J.M.,Santaguida, S.,Musacchio, A.,Knapp, S.
Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
J.Med.Chem., 55:7841-, 2012
Cited by
PubMed: 22920039
DOI: 10.1021/JM3008954
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.75 Å)
Structure validation

217705

건을2024-03-27부터공개중

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