4AC3

S.pneumoniae GlmU in complex with an antibacterial inhibitor

Summary for 4AC3

Entry DOI	10.2210/pdb4ac3/pdb
Related	4AA7 4AAW
Descriptor	BIFUNCTIONAL PROTEIN GLMU, N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)sulfamoyl]phenyl}acetamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, acetyl transferase, transferase-inhibitor complex
Biological source	STREPTOCOCCUS PNEUMONIAE
Cellular location	Cytoplasm : Q8DQ18
Total number of polymer chains	1
Total formula weight	50025.08
Authors	Otterbein, L.,Breed, J.,Ogg, D.J. (deposition date: 2011-12-12, release date: 2012-02-15, Last modification date: 2023-12-20)
Primary citation	Green, O.M.,McKenzie, A.R.,Shapiro, A.B.,Otterbein, L.,Ni, H.,Patten, A.,Stokes, S.,Albert, R.,Kawatkar, S.,Breed, J. Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series. Bioorg.Med.Chem.Lett., 22:1510-, 2012 Cited by PubMed: 22297115 DOI: 10.1016/J.BMCL.2012.01.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation