4AAA

Crystal structure of the human CDKL2 kinase domain

Summary for 4AAA

Entry DOI	10.2210/pdb4aaa/pdb
Descriptor	CYCLIN-DEPENDENT KINASE-LIKE 2, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transferase, phospho-mimetic
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q92772
Total number of polymer chains	1
Total formula weight	39188.30
Authors	Canning, P.,Vollmar, M.,Cooper, C.D.O.,Mahajan, P.,Daga, N.,Berridge, G.,Burgess-Brown, N.,Muniz, J.R.C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2011-11-30, release date: 2011-12-21, Last modification date: 2023-12-20)
Primary citation	Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175 DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation