4A7C

Crystal structure of PIM1 kinase with ETP46546

Summary for 4A7C

Entry DOI	10.2210/pdb4a7c/pdb
Related	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2
Descriptor	PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine, IMIDAZOLE, ... (5 entities in total)
Functional Keywords	transferase, protein kinase, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	35965.58
Authors	Mazzorana, M.,Montoya, G. (deposition date: 2011-11-12, release date: 2012-02-15, Last modification date: 2023-12-20)
Primary citation	Pastor, J.,Oyarzabal, J.,Saluste, G.,Alvarez, R.M.,Rivero, V.,Ramos, F.,Cendon, E.,Blanco-Aparicio, C.,Ajenjo, N.,Cebria, A.,Albarran, M.I.,Cebrian, D.,Corrionero, A.,Fominaya, J.,Montoya, G.,Mazzorana, M. Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-B]Pyridines as Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22:1591-, 2012 Cited by PubMed: 22266039 DOI: 10.1016/J.BMCL.2011.12.130 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation