4A79

Crystal structure of human monoamine oxidase B (MAO B) in complex with pioglitazone

4A79 の概要

• エントリーDOI: 10.2210/pdb4a79/pdb
• 関連するPDBエントリー: 1GOS 1H8R 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM 2VZ2 2XCG 2XFN 2XFO 2XFP 2XFQ 2XFU 3ZYX 4A7A
• 分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, anti-diabetes drug, parkinson's disease, neurodegeneration
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119959.44

構造登録者

Binda, C.,Aldeco, M.,Geldenhuys, W.J.,Tortorici, M.,Mattevi, A.,Edmondson, D.E. (登録日: 2011-11-11, 公開日: 2012-04-25, 最終更新日: 2023-12-20)

• 主引用文献: Binda, C.,Aldeco, M.,Geldenhuys, W.J.,Tortorici, M.,Mattevi, A.,Edmondson, D.E.; Molecular Insights Into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs; Acs Med. Chem. Lett., 3:39-42-, 2012; PubMed: 22282722; DOI: 10.1021/ML200196P

実験手法

X-RAY DIFFRACTION (1.89 Å)