4A7A

Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone

Summary for 4A7A

Entry DOI	10.2210/pdb4a7a/pdb
Related	1GOS 1H8R 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM 2VZ2 2XCG 2XFN 2XFO 2XFP 2XFQ 2XFU 3ZYX 4A79
Descriptor	AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (R)-ROSIGLITAZONE, ... (4 entities in total)
Functional Keywords	oxidoreductase, anti-diabetes drug, parkinson's disease, neurodegeneration
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	119961.41
Authors	Binda, C.,Aldeco, M.,Geldenhuys, W.J.,Tortorici, M.,Mattevi, A.,Edmondson, D.E. (deposition date: 2011-11-11, release date: 2012-04-25, Last modification date: 2023-12-20)
Primary citation	Binda, C.,Aldeco, M.,Geldenhuys, W.J.,Tortorici, M.,Mattevi, A.,Edmondson, D.E. Molecular Insights Into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs Acs Med. Chem. Lett., 3:39-42-, 2012 Cited by PubMed: 22282722 DOI: 10.1021/ML200196P PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation