4A6D

Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM

Summary for 4A6D

• Entry DOI: 10.2210/pdb4a6d/pdb
• Related: 4A6E
• Descriptor: HYDROXYINDOLE O-METHYLTRANSFERASE, ZINC ION, S-ADENOSYLMETHIONINE, ... (6 entities in total)
• Functional Keywords: transferase, melatonin, circadian clock
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 40484.40

Authors

Legrand, P.,Haouz, A.,Shepard, W. (deposition date: 2011-11-01, release date: 2012-11-07, Last modification date: 2013-08-28)

• Primary citation: Botros, H.G.,Legrand, P.,Pagan, C.,Bondet, V.,Weber, P.,Ben-Abdallah, M.,Lemiere, N.,Huguet, G.,Bellalou, J.,Maronde, E.,Beguin, P.,Haouz, A.,Shepard, W.,Bourgeron, T.; Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.; J.Pineal Res., 54:46-, 2013; PubMed: 22775292; DOI: 10.1111/J.1600-079X.2012.01020.X

Experimental method

X-RAY DIFFRACTION (2.4 Å)