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4A6D

Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM

Functional Information from GO Data
ChainGOidnamespacecontents
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006629biological_processlipid metabolic process
A0008168molecular_functionmethyltransferase activity
A0008171molecular_functionO-methyltransferase activity
A0008172molecular_functionS-methyltransferase activity
A0017096molecular_functionacetylserotonin O-methyltransferase activity
A0030187biological_processmelatonin biosynthetic process
A0032259biological_processmethylation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0046219biological_processindolalkylamine biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 1348
ChainResidue
AGLU267
AHIS271
AHOH2041
AHOH2057
AHOH2065

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN A 1349
ChainResidue
AMET319
AMET319

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE SAM A 1350
ChainResidue
ALEU160
ATRP164
AGLY187
AASP210
AILE211
AVAL214
AGLY235
AASP236
APHE237
APHE238
AALA251
AARG252
AASP256
AHOH2018
AHOH2026
APHE143
ATYR147

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1351
ChainResidue
AHIS318
AARG327
AASP328
APHE329

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1352
ChainResidue
ALYS107
AARG111

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1353
ChainResidue
ALYS74
ATHR87
AGLU88

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1354
ChainResidue
AHIS264
AARG268
AGLY346
ATHR347
AHOH2059

site_idAC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE GOL A 1355
ChainResidue
ALEU31

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:22775292
ChainResidueDetails
AHIS255

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING:
ChainResidueDetails
ATYR147
ATRP164
AASP210
AGLY235
AARG252
AASP256
AASN302
AGLN306

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PDB entries from 2024-05-01

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