4A6A

A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP

Summary for 4A6A

• Entry DOI: 10.2210/pdb4a6a/pdb
• Descriptor: DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase, deoxy-ribonucleotide metabolism, dttp inhibition
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 12
• Total formula weight: 257162.16

Authors

Lovgreen, M.N.,Ucar, E.,Willemoes, M.,Harris, P. (deposition date: 2011-11-01, release date: 2012-10-10, Last modification date: 2017-11-08)

• Primary citation: Lovgreen, M.N.,Harris, P.,Ucar, E.,Willemoes, M.; Dttp Inhibition of the Bifunctional Dctp Deaminase- Dutpase from Mycobacterium Tuberculosis is Ph Dependent: Kinetic Analyses and Crystal Structure of A115V Variant; To be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)