4A6A
A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP
Summary for 4A6A
Entry DOI | 10.2210/pdb4a6a/pdb |
Descriptor | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | hydrolase, deoxy-ribonucleotide metabolism, dttp inhibition |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 12 |
Total formula weight | 257162.16 |
Authors | Lovgreen, M.N.,Ucar, E.,Willemoes, M.,Harris, P. (deposition date: 2011-11-01, release date: 2012-10-10, Last modification date: 2024-05-08) |
Primary citation | Lovgreen, M.N.,Harris, P.,Ucar, E.,Willemoes, M. Dttp Inhibition of the Bifunctional Dctp Deaminase- Dutpase from Mycobacterium Tuberculosis is Ph Dependent: Kinetic Analyses and Crystal Structure of A115V Variant To be Published, |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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