4ZLY

Crystal Structure of Bruton's Tyrosine Kinase bound to a Cinnoline Fragment

Summary for 4ZLY

Entry DOI	10.2210/pdb4zly/pdb
Related	4ZLZ
Descriptor	Tyrosine-protein kinase BTK, IMIDAZOLE, ISOPROPYL ALCOHOL, ... (6 entities in total)
Functional Keywords	cytoplasmic tyrosine kinase, transcriptional regulation, nuclear factor-kappab, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q06187
Total number of polymer chains	1
Total formula weight	31975.79
Authors	Dougan, D.R. (deposition date: 2015-05-01, release date: 2015-07-01, Last modification date: 2024-03-06)
Primary citation	Smith, C.R.,Dougan, D.R.,Komandla, M.,Kanouni, T.,Knight, B.,Lawson, J.D.,Sabat, M.,Taylor, E.R.,Vu, P.,Wyrick, C. Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 58:5437-5444, 2015 Cited by PubMed: 26087137 DOI: 10.1021/acs.jmedchem.5b00734 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation