4ZJS
Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.
Summary for 4ZJS
Entry DOI | 10.2210/pdb4zjs/pdb |
Descriptor | Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor, 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone (3 entities in total) |
Functional Keywords | anatoxin-a, nicotinic, receptor, acetylcholine, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 132041.90 |
Authors | Talley, T.T.,Bobango, J.,Wu, J.,Park, J.F.,Luo, J.,Lindsatrom, J.,Taylor, P. (deposition date: 2015-04-29, release date: 2015-05-13, Last modification date: 2023-09-27) |
Primary citation | Luo, J.,Taylor, P.,Losen, M.,de Baets, M.H.,Shelton, G.D.,Lindstrom, J. Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. J. Neurosci., 29:13898-13908, 2009 Cited by PubMed: 19890000DOI: 10.1523/JNEUROSCI.2833-09.2009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2301 Å) |
Structure validation
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