4Z93
BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18.
Summary for 4Z93
Entry DOI | 10.2210/pdb4z93/pdb |
Descriptor | Bromodomain-containing protein 4, 1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indole, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 13734.99 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2015-04-09, release date: 2015-07-01, Last modification date: 2023-09-27) |
Primary citation | Ran, X.,Zhao, Y.,Liu, L.,Bai, L.,Yang, C.Y.,Zhou, B.,Meagher, J.L.,Chinnaswamy, K.,Stuckey, J.A.,Wang, S. Structure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J.Med.Chem., 58:4927-4939, 2015 Cited by PubMed: 26080064DOI: 10.1021/acs.jmedchem.5b00613 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
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