4Z78

Weak TCR binding to an unstable insulin epitope drives type 1 diabetes

Summary for 4Z78

Entry DOI	10.2210/pdb4z78/pdb
Descriptor	H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, Insulin, ... (7 entities in total)
Functional Keywords	immunoglobulin, h-2kd, type 1 diabetes, immune system
Biological source	Mus musculus (House Mouse) More
Cellular location	Membrane; Single-pass type I membrane protein: P01902 Secreted : P61769 P01308
Total number of polymer chains	9
Total formula weight	137896.68
Authors	Rizkallah, P.J.,Cole, D.K. (deposition date: 2015-04-06, release date: 2015-06-24, Last modification date: 2015-08-12)
Primary citation	Motozono, C.,Pearson, J.A.,De Leenheer, E.,Rizkallah, P.J.,Beck, K.,Trimby, A.,Sewell, A.K.,Wong, F.S.,Cole, D.K. Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide. J.Biol.Chem., 290:18924-18933, 2015 Cited by PubMed: 26085090 DOI: 10.1074/jbc.M114.622522 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.304 Å)

Structure validation