4Z78
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (A, D, G) | H-2 class I histocompatibility antigen, K-D alpha chain | polymer | 277 | 32353.0 | 3 | UniProt (P01902) Pfam (PF00129) Pfam (PF07654) | Mus musculus (House Mouse) | Leukocyte antigen heavy chain, H-2K(D) |
| 2 | B, E, H (B, E, H) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 3 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C, F, I (C, F, I) | Insulin | polymer | 10 | 1157.4 | 3 | UniProt (P01308) | Homo sapiens (Human) | |
| 4 | AA, J, K, L, S (H, A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | BA, CA, M, N, T... (H, A, D, E) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | O, P, Q, R, U... (A, D, G) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 7 | DA, EA, FA, GA, HA... (A, B, D, E, G...) | water | water | 18.0 | 364 | Chemie (HOH) |
Sequence modifications
A, D, G: 1 - 275 (UniProt: P01902)
B, E, H: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| His 114 | Gln 135 | conflict |
| Pro 276 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 136169.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1727.5 | |
| All* | Total formula weight | 137896.7 |
