4Z3K
Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid
Summary for 4Z3K
Entry DOI | 10.2210/pdb4z3k/pdb |
Related | 4XWY |
Descriptor | Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Xanthuric acid, ... (6 entities in total) |
Functional Keywords | sepiapterin-reductase, xanthurenic acid, inhibitor, tryptophan-metabolite, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P35270 |
Total number of polymer chains | 4 |
Total formula weight | 123998.39 |
Authors | Johnsson, K. (deposition date: 2015-03-31, release date: 2015-11-18, Last modification date: 2024-01-10) |
Primary citation | Haruki, H.,Hovius, R.,Pedersen, M.G.,Johnsson, K. Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. J.Biol.Chem., 291:652-657, 2016 Cited by PubMed: 26565027DOI: 10.1074/jbc.C115.680488 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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