4YMA

Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109

Summary for 4YMA

• Entry DOI: 10.2210/pdb4yma/pdb
• Related: 1FW0
• Descriptor: Glutamate receptor 2, SULFATE ION, GLYCEROL, ... (7 entities in total)
• Functional Keywords: ionotropic glutamate receptor, ampa receptor glua2, ligand-binding domain, antagonist, signaling protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P19491
• Total number of polymer chains: 2
• Total formula weight: 60003.68

Authors

Moller, C.,Tapken, D.,Kastrup, J.S.,Frydenvang, K. (deposition date: 2015-03-06, release date: 2015-08-05, Last modification date: 2024-01-10)

• Primary citation: Krogsgaard-Larsen, N.,Storgaard, M.,Moller, C.,Demmer, C.S.,Hansen, J.,Han, L.,Monrad, R.N.,Nielsen, B.,Tapken, D.,Pickering, D.S.,Kastrup, J.S.,Frydenvang, K.,Bunch, L.; Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.; J.Med.Chem., 58:6131-6150, 2015; PubMed: 26200741; DOI: 10.1021/acs.jmedchem.5b00750

Experimental method

X-RAY DIFFRACTION (1.895 Å)