4YMA

Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS144
B	ARG148
B	ARG163
B	HOH409
B	HOH410
B	HOH428

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 B 302

Chain	Residue
B	HOH767
B	HOH770
B	HOH774
B	HOH775
B	LYS60
B	TYR61
B	4E5304

---

site_id	AC3
Number of Residues	2
Details	binding site for residue GOL B 303

Chain	Residue
B	HIS46
B	LYS240

---

site_id	AC4
Number of Residues	16
Details	binding site for residue 4E5 B 304

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	SER142
B	THR143
B	GLU193
B	SO4302
B	HOH522
B	HOH532
B	HOH571
B	HOH735
B	HOH763
B	HOH774

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO B 305

Chain	Residue
A	LEU26
B	GLU30
B	HOH433
B	HOH526

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO B 306

Chain	Residue
B	LYS116
B	HOH588

---

site_id	AC7
Number of Residues	7
Details	binding site for residue ACT A 301

Chain	Residue
A	PRO105
A	PHE106
A	MET107
A	SER108
A	ASN242
A	HOH611
B	SER217

---

site_id	AC8
Number of Residues	1
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS185

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	LYS144
A	ARG148
A	HOH404
A	HOH676

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS82
A	LYS185
A	HOH428
A	HOH432

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS60
A	TYR61
A	4E5307
A	HOH664
A	HOH695
A	HOH703

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL A 306

Chain	Residue
A	HIS46
A	ALA233
A	LEU236
A	ALA237
A	LYS240
A	HOH687

---

site_id	AD4
Number of Residues	14
Details	binding site for residue 4E5 A 307

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	SER142
A	THR143
A	GLU193
A	SO4305
A	HOH504
A	HOH527
A	HOH571
A	HOH691

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---