4YMA

Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Glutamate receptor 2	polymer	264	29278.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	C, D, J, K, L... (B, A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	E, N (B, A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	F, O (B, A)	(3R)-3-(3-carboxy-5-hydroxyphenyl)-L-proline	non-polymer		251.2	2	Chemie (4E5)
5	G, H (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	I (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
7	P, Q (B, A)	water	water		18.0	698	Chemie (HOH)

Sequence modifications

B, A: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

B, A: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58557.5
Non-Polymers*	Number of molecules	13
	Total formula weight	1446.2
All*	Total formula weight	60003.7

*Water molecules are not included.