4YIH

Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU

Summary for 4YIH

• Entry DOI: 10.2210/pdb4yih/pdb
• Descriptor: 5'(3')-deoxyribonucleotidase, cytosolic type, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: 5'-nucleotidase, dephosphorylation, phosphorylation, had-like, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 46945.58

Authors

Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2015-03-02, release date: 2015-09-09, Last modification date: 2024-01-10)

• Primary citation: Pachl, P.,Simak, O.,Rezacova, P.,Fabry, M.,Budesinsky, M.,Rosenberg, I.,Brynda, J.; Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor; Medchemcomm, 6:1635-1638, 2015; DOI: 10.1039/C5MD00235D

Experimental method

X-RAY DIFFRACTION (1.82 Å)