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4YFK

Escherichia coli RNA polymerase in complex with squaramide compound 8.

Summary for 4YFK
Entry DOI10.2210/pdb4yfk/pdb
Related4YFN 4YFX
DescriptorDNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
Functional Keywordsswitch region, squaramide, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceEscherichia coli O139:H28 (strain E24377A / ETEC)
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Total number of polymer chains12
Total formula weight921059.50
Authors
Molodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S. (deposition date: 2015-02-25, release date: 2015-03-11, Last modification date: 2023-09-27)
Primary citationMolodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S.
X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58:3156-3171, 2015
Cited by
PubMed: 25798859
DOI: 10.1021/acs.jmedchem.5b00050
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.571 Å)
Structure validation

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