4YFK

Escherichia coli RNA polymerase in complex with squaramide compound 8.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, G, H	DNA-directed RNA polymerase subunit alpha	polymer	329	36558.7	4	UniProt (A7ZSI4) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) In PDB	Escherichia coli O139:H28 (strain E24377A / ETEC)	RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
2	C, I	DNA-directed RNA polymerase subunit beta	polymer	1342	150820.9	2	UniProt (A7ZUK1) Pfam (PF04560) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) In PDB	Escherichia coli O139:H28 (strain E24377A / ETEC)	RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
3	D, J	DNA-directed RNA polymerase subunit beta'	polymer	1407	155366.8	2	UniProt (A7ZUK2) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB	Escherichia coli O139:H28 (strain E24377A / ETEC)	RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
4	E, K	DNA-directed RNA polymerase subunit omega	polymer	91	10249.5	2	UniProt (A7ZTK1) Pfam (PF01192) In PDB	Escherichia coli O139:H28 (strain E24377A / ETEC)	RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
5	F, L	RNA polymerase sigma factor RpoD	polymer	613	70352.2	2	UniProt (P00579) Pfam (PF03979) Pfam (PF00140) Pfam (PF04546) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) In PDB	Escherichia coli (strain K12)	Sigma-70
6	C, D, I, J	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	D, J	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
8	D, J	3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide	non-polymer		443.5	2	Chemie (4C6)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	919813.6
Non-Polymers*	Number of molecules	10
	Total formula weight	1245.9
All*	Total formula weight	921059.5

*Water molecules are not included.