4YC7

Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp

Summary for 4YC7

• Entry DOI: 10.2210/pdb4yc7/pdb
• Descriptor: Formin-like protein 2, Cell division control protein 42 homolog, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: signaling protein, armadillo repeat, rho gtpase, cell cycle
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q96PY5; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P60953
• Total number of polymer chains: 2
• Total formula weight: 64655.65

Authors

Kuhn, S.,Geyer, M. (deposition date: 2015-02-19, release date: 2015-05-13, Last modification date: 2024-01-10)

• Primary citation: Kuhn, S.,Erdmann, C.,Kage, F.,Block, J.,Schwenkmezger, L.,Steffen, A.,Rottner, K.,Geyer, M.; The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.; Nat Commun, 6:7088-7088, 2015; PubMed: 25963737; DOI: 10.1038/ncomms8088

Experimental method

X-RAY DIFFRACTION (2.5 Å)