4Y6R

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC137, and manganese

Summary for 4Y6R

Entry DOI	10.2210/pdb4y6r/pdb
Related	4Y67 4Y6P
Descriptor	1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, {(2R)-4-[hydroxy(methyl)amino]-4-oxo-2-phenylbutyl}phosphonic acid, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	enzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase
Biological source	Plasmodium falciparum (isolate 3D7)
Cellular location	Plastid, apicoplast : Q8IKG4
Total number of polymer chains	2
Total formula weight	97116.79
Authors	Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2015-02-13, release date: 2015-04-01, Last modification date: 2024-01-10)
Primary citation	Chofor, R.,Sooriyaarachchi, S.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Johny, C.,Haymond, A.,Everaert, A.,Dowd, C.S.,Maes, L.,Coenye, T.,Alex, A.,Couch, R.D.,Jones, T.A.,Wouters, J.,Mowbray, S.L.,Van Calenbergh, S. Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase. J.Med.Chem., 58:2988-3001, 2015 Cited by PubMed: 25781377 DOI: 10.1021/jm5014264 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation