4Y6R
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC137, and manganese
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast | polymer | 422 | 48164.5 | 2 | UniProt (Q8IKG4) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) In PDB | Plasmodium falciparum (isolate 3D7) | DXP reductoisomerase |
2 | A, B | {(2R)-4-[hydroxy(methyl)amino]-4-oxo-2-phenylbutyl}phosphonic acid | non-polymer | 273.2 | 2 | Chemie (RF7) | |||
3 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 454 | Chemie (HOH) |
Sequence modifications
A, B: 75 - 488 (UniProt: Q8IKG4)
PDB | External Database | Details |
---|---|---|
Met 67 | - | initiating methionine |
Ala 68 | - | expression tag |
His 69 | - | expression tag |
His 70 | - | expression tag |
His 71 | - | expression tag |
His 72 | - | expression tag |
His 73 | - | expression tag |
His 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 96329.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 787.8 | |
All* | Total formula weight | 97116.8 |