4Y32
Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma
Summary for 4Y32
Entry DOI | 10.2210/pdb4y32/pdb |
Related | 4FL5 4Y3B 4Y3V 4Y5I |
Descriptor | 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC, (2S)-2-(2-methoxyethyl)pyrrolidine, ... (4 entities in total) |
Functional Keywords | peptide-hybrid, inhibitor, protein-protein interaction, peptide binding protein, adapter protein, 14-3-3, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 54918.75 |
Authors | Bartel, M.,Milroy, L.,Bier, D.,Brunsveld, L.,Ottmann, C. (deposition date: 2015-02-10, release date: 2015-12-23, Last modification date: 2024-01-10) |
Primary citation | Milroy, L.G.,Bartel, M.,Henen, M.A.,Leysen, S.,Adriaans, J.M.,Brunsveld, L.,Landrieu, I.,Ottmann, C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54:15720-15724, 2015 Cited by PubMed: 26537010DOI: 10.1002/anie.201507976 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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