4Y2B
Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A
Summary for 4Y2B
Entry DOI | 10.2210/pdb4y2b/pdb |
Descriptor | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde7a, camp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946 |
Total number of polymer chains | 1 |
Total formula weight | 44953.31 |
Authors | Endo, Y.,Kawai, K.,Asano, T.,Amano, S.,Asanuma, Y.,Sawada, K.,Onodera, Y.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Kamei, N.,Irie, T. (deposition date: 2015-02-09, release date: 2015-04-08, Last modification date: 2023-11-08) |
Primary citation | Endo, Y.,Kawai, K.,Asano, T.,Amano, S.,Asanuma, Y.,Sawada, K.,Onodera, Y.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Kamei, N.,Irie, T. 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy Bioorg.Med.Chem.Lett., 25:1910-1914, 2015 Cited by PubMed: 25866242DOI: 10.1016/j.bmcl.2015.03.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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