4Y2B
Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | polymer | 389 | 44549.2 | 1 | UniProt (Q13946) Pfam (PF00233) In PDB | Homo sapiens (Human) | HCP1,TM22 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | 3-ethyl-2-(propan-2-ylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one | non-polymer | 314.4 | 1 | Chemie (EPK) | |||
5 | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A: 130 - 482 (UniProt: Q13946)
PDB | External Database | Details |
---|---|---|
Gly 94 | - | expression tag |
Ser 95 | - | expression tag |
Gly 96 | - | expression tag |
Met 97 | - | expression tag |
Lys 98 | - | expression tag |
Glu 99 | - | expression tag |
Thr 100 | - | expression tag |
Ala 101 | - | expression tag |
Ala 102 | - | expression tag |
Ala 103 | - | expression tag |
Lys 104 | - | expression tag |
Phe 105 | - | expression tag |
Glu 106 | - | expression tag |
Arg 107 | - | expression tag |
Gln 108 | - | expression tag |
His 109 | - | expression tag |
Met 110 | - | expression tag |
Asp 111 | - | expression tag |
Ser 112 | - | expression tag |
Pro 113 | - | expression tag |
Asp 114 | - | expression tag |
Leu 115 | - | expression tag |
Gly 116 | - | expression tag |
Thr 117 | - | expression tag |
Asp 118 | - | expression tag |
Asp 119 | - | expression tag |
Asp 120 | - | expression tag |
Asp 121 | - | expression tag |
Lys 122 | - | expression tag |
Ala 123 | - | expression tag |
Met 124 | - | expression tag |
Ala 125 | - | expression tag |
Asp 126 | - | expression tag |
Ile 127 | - | expression tag |
Gly 128 | - | expression tag |
Ser 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 44549.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 404.1 | |
All* | Total formula weight | 44953.3 |