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4Y2B

Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS216
AHIS252
AASP253
AASP362
AMG502
AHOH686
AHOH883

site_idAC2
Number of Residues7
Detailsbinding site for residue MG A 502
ChainResidue
AHOH687
AHOH688
AHOH689
AHOH690
AHOH883
AASP253
AZN501

site_idAC3
Number of Residues12
Detailsbinding site for residue EPK A 503
ChainResidue
ATYR211
AASN365
AVAL380
ALYS393
ATYR394
ALEU401
AILE412
AGLN413
APHE416
AHOH641
AHOH713
AHOH818

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvnQpF
ChainResidueDetails
AHIS252-PHE263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS212

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:15994308, ECO:0000269|PubMed:19350606
ChainResidueDetails
AASP362
AHIS216
AHIS252
AASP253

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PDB entries from 2024-06-12

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