4Y29
Identification of a novel PPARg ligand that regulates metabolism
Summary for 4Y29
Entry DOI | 10.2210/pdb4y29/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, ... (4 entities in total) |
Functional Keywords | af-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator pparg, nr1c3, peroxisome proliferator-activated receptor gamma, nhr, nuclear receptor, coactivator, transcription factor, dna binding protein-transcription complex, dna binding protein/transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P37231 Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32226.49 |
Authors | |
Primary citation | Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y. Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency. Sci Rep, 5:12222-12222, 2015 Cited by PubMed: 26183621DOI: 10.1038/srep12222 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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