4XUH
PPARgamma ligand binding domain in complex with sulindac sulfide
Summary for 4XUH
| Entry DOI | 10.2210/pdb4xuh/pdb |
| Related | 3SZ1 4XTA |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid (3 entities in total) |
| Functional Keywords | nuclear receptor, ppargamma, sulindac sulfide, nsaids, translation |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: P37231 |
| Total number of polymer chains | 2 |
| Total formula weight | 64831.37 |
| Authors | Puhl, A.C.,Polikaporv, I.,Webb, P. (deposition date: 2015-01-25, release date: 2016-07-27, Last modification date: 2023-09-27) |
| Primary citation | Puhl, A.C.,Milton, F.A.,Cvoro, A.,Sieglaff, D.H.,Campos, J.C.,Bernardes, A.,Filgueira, C.S.,Lindemann, J.L.,Deng, T.,Neves, F.A.,Polikarpov, I.,Webb, P. Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13:e004-e004, 2015 Cited by PubMed: 26445566DOI: 10.1621/nrs.13004 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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