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4XUH

PPARgamma ligand binding domain in complex with sulindac sulfide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue SFI A 501
ChainResidue
AGLU259
APHE264
AARG280
AILE281
ACYS285
AILE341
ASER342
AHOH603
AHOH605

site_idAC2
Number of Residues12
Detailsbinding site for residue SFI A 502
ChainResidue
APHE282
ACYS285
AGLN286
ASER289
AHIS323
ATYR327
ALEU356
APHE360
APHE363
AHIS449
ALEU469
ATYR473

site_idAC3
Number of Residues14
Detailsbinding site for residue SFI B 501
ChainResidue
BILE281
BCYS285
BARG288
BSER289
BILE326
BMET329
BLEU330
BLEU333
BVAL339
BLEU340
BILE341
BSFI502
BHOH644
BHOH676

site_idAC4
Number of Residues16
Detailsbinding site for residue SFI B 502
ChainResidue
BCYS285
BGLN286
BSER289
BHIS323
BILE326
BLEU330
BMET334
BVAL339
BLEU353
BPHE363
BMET364
BLYS367
BHIS449
BLEU453
BSFI501
BHOH630

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

226707

PDB entries from 2024-10-30

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