4XAK

Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD

Summary for 4XAK

• Entry DOI: 10.2210/pdb4xak/pdb
• Descriptor: Spike glycoprotein, Heavy chain of neutralizing antibody m336, Light chain of neutralizing antibody m336, ... (6 entities in total)
• Functional Keywords: mers-cov rbd, antibody m336, neutralization, immune system
• Biological source: Human coronavirus EMC (HCoV-EMC); More
• Cellular location: Spike protein S2: Virion membrane ; Single-pass type I membrane protein . Spike protein S1: Virion membrane ; Peripheral membrane protein : K9N5Q8
• Total number of polymer chains: 6
• Total formula weight: 155793.68

Authors

Zhou, T.,Dimtrov, D.S.,Ying, T. (deposition date: 2014-12-15, release date: 2015-08-26, Last modification date: 2023-09-27)

• Primary citation: Ying, T.,Prabakaran, P.,Du, L.,Shi, W.,Feng, Y.,Wang, Y.,Wang, L.,Li, W.,Jiang, S.,Dimitrov, D.S.,Zhou, T.; Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.; Nat Commun, 6:8223-8223, 2015; PubMed: 26370782; DOI: 10.1038/ncomms9223

Experimental method

X-RAY DIFFRACTION (2.45 Å)